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Tandem Mass Spectrometry

Tandem Mass Spectrometry

Tandem mass spectrometry is a technique that uses multiple mass analyzers in series to obtain a higher selectivity and reduce chemical noise during analyte detection. Instruments with multiple analyzers separated by an interaction cell enable secondary fragmentation and selected study of the fragment ions.Secondary fragmentations occur in the interaction cell and can be induced by various factors. Fragmentation induced by collision with inert gases, such as N2, Ar, He, etc., is called...

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Updated: Jun 26, 2026

A Strategy for Sensitive, Large Scale Quantitative Metabolomics

A Strategy for Sensitive, Large Scale Quantitative Metabolomics

Published on: May 27, 2014

CE-MS in metabolomics.

Rawi Ramautar¹, Govert W Somsen, Gerhardus J de Jong

¹Department of Biomedical Analysis, Utrecht University, Sorbonnelaan, Utrecht, The Netherlands.

Electrophoresis

|December 25, 2008

Summary

This summary is machine-generated.

Capillary Electrophoresis-Mass Spectrometry (CE-MS) is a powerful tool for metabolomics, enabling comprehensive analysis of polar metabolites in various biological samples. This review highlights CE-MS techniques and applications in biological research.

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Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS)

Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS)

Published on: March 14, 2013

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Last Updated: Jun 26, 2026

A Strategy for Sensitive, Large Scale Quantitative Metabolomics

A Strategy for Sensitive, Large Scale Quantitative Metabolomics

Published on: May 27, 2014

Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS)

Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS)

Published on: March 14, 2013

Area of Science:

Analytical Chemistry
Biochemistry
Systems Biology

Background:

Metabolomics involves the comprehensive analysis of small molecules within biological systems.
Capillary Electrophoresis-Mass Spectrometry (CE-MS) is a key technique for profiling polar metabolites.
Understanding metabolic profiles is crucial for various biological and medical research areas.

Purpose of the Study:

To provide an overview of Capillary Electrophoresis-Mass Spectrometry (CE-MS) applications in metabolomics.
To review various CE separation modes, MS analyzers, and sample preparation techniques used in CE-MS for metabolomics.
To discuss future trends and potential advancements in CE-MS for metabolomics.

Main Methods:

Review of scientific literature on CE-MS in metabolomics from 2000-2008.
Analysis of different CE separation modes, capillary coatings, and MS analyzers.
Examination of sample preparation and data analysis methodologies for CE-MS.

Main Results:

CE-MS is effective for profiling polar metabolites in diverse biological samples, including bacterial and plant extracts, urine, plasma, and cerebrospinal fluid.
A tabular summary of relevant CE-MS metabolomics studies (2000-2008) is presented, detailing sample types and MS detection modes.
Various CE-MS configurations and analytical strategies have been successfully applied to metabolomics research.

Conclusions:

CE-MS is a versatile and powerful technique for comprehensive metabolomic profiling.
Future developments in ionization techniques, coupled separation systems, and microchip CE hold significant promise for advancing metabolomics.
Continued refinement of CE-MS methods will enhance its utility in biological and clinical research.