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Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Introduction to Biological Bases of Psychology01:30

Introduction to Biological Bases of Psychology

Biopsychology serves as a vital bridge connecting the intricate domains of biology and psychology, shedding light on how biological systems influence psychological phenomena. This field scrutinizes the biological substrates of behavior and mental processes, emphasizing the nervous system along with the roles of neurotransmitters, hormones, and genetics. It also incorporates evolutionary perspectives to explain the adaptive nature of mental functions.
The nervous system, the cornerstone of...
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Organization of the Nervous System01:13

Organization of the Nervous System

The nervous system is one of the most complex systems in our body. It is organized into two main divisions: the central nervous system (CNS) and the peripheral nervous system (PNS).
The CNS, comprising the brain and spinal cord, houses billions of neurons. The brain is housed in the skull, while the spinal cord is linked to the brain through the foramen magnum of the occipital bone and is surrounded by the protective structure of the vertebral column. It is responsible for processing various...

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Related Experiment Video

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Quantification of Global Histone Post Translational Modifications Using Intranuclear Flow Cytometry in Isolated Mouse Brain Microglia
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Epigenetics and the nervous system.

Mark F Mehler1

  • 1Institute for Brain Disorders and Neural Regeneration, Albert Einstein College of Medicine, Bronx, NY 10461, USA. mehler@aecom.yu.edu

Annals of Neurology
|December 25, 2008
PubMed
Summary
This summary is machine-generated.

Genomic sciences are revolutionizing biology and medicine, especially for brain function and neurological diseases. Epigenetic principles offer new ways to understand and treat brain disorders, promoting recovery and prevention.

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Area of Science:

  • Genomic Sciences
  • Neuroscience
  • Epigenetics

Background:

  • Genomic sciences are transforming biology and medicine.
  • Epigenetic principles are key to understanding neurological disease.
  • Current understanding of brain function, development, and disease is evolving.

Purpose of the Study:

  • To highlight the revolutionary impact of genomic sciences on understanding the brain.
  • To emphasize the role of epigenetics in neurological disease.
  • To introduce the potential of epigenomic medicine for neurological therapeutics.

Main Methods:

  • Application of epigenetic principles.
  • Identification of molecular signatures.
  • Characterization of disease mechanisms.
  • Analysis of therapeutic responses.

Main Results:

  • Discovery of unrecognized molecular signatures for disease latency, onset, and progression.
  • Elucidation of mechanisms underlying neurological disease pathogenesis.
  • Understanding of responses to novel therapeutic modalities.

Conclusions:

  • Epigenomic medicine heralds a new era for neurological therapeutics.
  • Potential for disease prevention and recovery of neurological function.
  • Therapeutic strategies include stem cell reprogramming and modulation of neural plasticity.