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Updated: Jun 26, 2026

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
Published on: September 18, 2020
Decreased expression of 15-hydroxyprostaglandin dehydrogenase in gastric carcinomas
Tae Jung Jang1, Ye Seob Ji, Ki Hoon Jung
1Department of Pathology, Dongguk University College of Medicine, 707 Sukjang-dong, Kyongju, Kyongbuk 780-714, Korea. taejung@mail.dongguk.ac.kr
Purpose:
Gastric carcinoma tissues release high level of prostaglandin E2 (PGE2) when compared to non-neoplastic mucosa, and cyclooxygenase-2 (COX-2), which is the rate-limiting enzyme in prostaglandin (PG) biosynthesis, is often overexpressed in gastric carcinomas and during gastric carcinogenesis. However, little is known about the expression of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), the key enzyme responsible for the biological inactivation of PG, in gastric carcinomas.
Materials And Methods:
We investigated the expression of 15-PGDH in 28 cases of advanced gastric carcinomas by Western blot analysis and also the relation between its expression and the gene promoter methylation.
Results:
15-PGDH expression was significantly decreased in gastric carcinomas compared to corresponding non-neoplastic tissues and inversely correlated with the expression of proliferating cell nuclear antigen in gastric carcinomas. However, there was no correlation between 15-PGDH expression and pathological findings such as nodal metastasis and vascular invasion. Promoter hypermethylation of 15-PGDH gene was not detected in carcinomas, with only a negligible expression of the enzyme.
Conclusion:
Our results suggested that 15-PGDH has tumor suppressor activity in gastric carcinomas.
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