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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
Published on: December 11, 2017
Gender- and age-related outcomes of cardiac resynchronization therapy: a pilot observational study
Ramezan Bakhshian Kelarijani1, Davoud Kazemi Saleh, Majid Chalian
1Clinical Research Unit, Baqiyatallah University of Medical Sciences, Tehran, Iran. parsi.bakhshian@gmail.com
Insights
Cardiac resynchronization therapy (CRT) improved heart failure symptoms and measures in patients regardless of age or gender. This study found no significant differences in CRT response based on age or sex at 3- and 6-month follow-ups.
Area of Science:
- Cardiology
- Medical Devices
- Heart Failure Management
Background:
- Cardiac resynchronization therapy (CRT) is used to treat heart failure (HF), improving patient outcomes.
- However, its effectiveness in specific patient subgroups, such as by age and gender, requires further investigation.
Purpose of the Study:
- To evaluate the relationship between CRT response and patient characteristics, specifically gender and age.
- To determine if age or gender influences the success of CRT in patients with severe heart failure.
Main Methods:
- A longitudinal observational study included 65 Iranian patients with severe HF (NYHA class III/IV, LVEF ≤35%, QRS duration >120 ms).
- Clinical, electrophysiologic, and echocardiographic assessments were conducted before CRT implantation and at 3 and 6 months post-implantation.
Main Results:
- Significant improvements in NYHA class, QRS duration, LVEF, and LVEDD were observed at 3 and 6 months in all patient groups (by age and gender).
- No significant differences in the improvement of these parameters were found between age groups (<60 vs. >60 years) or between genders at either follow-up point.
Conclusions:
- CRT response in patients with severe heart failure appears not to be significantly related to gender or age.
- Larger studies are recommended to confirm these findings regarding CRT effectiveness across different demographic subgroups.
Background:
Cardiac resynchronization therapy (CRT) has been reported to improve clinical status and survival, and shorten hospitalization rates, in patients with heart failure (HF). However, questions remain regarding the success of CRT in different subgroups of patients with HE.
Objective:
We assessed whether CRT response was related to gender or age in patients with HE.
Methods:
In a longitudinal observational study, patients with severe HF (New York Heart Association [NYHA] class III or IV, left ventricular ejection fraction [LVEF]
Results:
A total of 65 Iranian patients (50 men, 15 women; mean [SD] age, 60.3 [10.3] years; baseline NYHA class, 3.1 [0.36]; QRS duration, 144 [14] ms; LVEF, 21% [7.3%]; left ventricular end-diastolic diameter (LVEDD), 6.8 [0.56] mm) were evaluated. NYHA class, QRS duration, LVEF, and LVEDD were significantly improved at 3- and 6-month follow-ups both in patients aged
Conclusion:
CRT response in these patients with HF did not appear to be gender or age related at 3- and 6-month follow-ups in this small observational study. Confirmation of these findings by larger studies is needed.
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