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Updated: Jun 26, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Gastroesophageal reflux and obstructive sleep apnea in childhood
Alessandra Caland Noronha1, Veralice Meireles Sales de Bruin, Miguel Angelo Nobre e Souza
1Department of Medicine, Federal University of Ceará, Brazil.
Insights
Gastroesophageal reflux (GER) is common in children with obstructive sleep apnea syndrome (OSAS). GER severity correlates with emotional distress and daytime issues in pediatric OSAS patients.
Area of Science:
- Pediatric Sleep Medicine
- Gastroenterology
Background:
- Obstructive sleep apnea syndrome (OSAS) is prevalent in children with adenotonsillar hypertrophy.
- Gastroesophageal reflux (GER) is a common comorbidity in pediatric populations.
Purpose of the Study:
- To investigate the relationship between GER and OSAS in children.
- To assess polysomnographic alterations and symptom severity in relation to GER.
Main Methods:
- Eighteen children (6-12 years) with OSAS underwent polysomnography and esophageal pH monitoring.
- Evaluations included the OSA-18 questionnaire and nasofibrolaryngoscopy.
Main Results:
- All children had OSAS (Apnea-index >= 1/hour).
- GER parameters did not correlate with OSAS severity or apnea events.
- GER severity correlated with emotional distress (p=0.008) and daytime problems (p=0.03) via OSA-18.
Conclusions:
- GER is frequent in children aged 6-12 with OSAS and warrants assessment.
- Increased GER severity is linked to emotional distress and daytime difficulties in pediatric OSAS.
Objectives:
To examine the relationship between gastroesophageal reflux (GER) and obstructive sleep apnea syndrome (OSAS) with polysomnographic alterations and symptom severity.
Patients And Methods:
Eighteen children aged from 6 to 12 years (8.14+/-1.75) with adenotonsillar hypertrophy and OSAS were evaluated with the OSA-18 questionnaire nasofibrolaringoscopy and full overnight polysomnography performed simultaneously with esophageal pH monitoring.
Results:
OSAS (Apnea-index (AI)>or=1/hour) was present in all cases. Reflux parameters did not correlate to OSAS severity and a temporal relationship between GER and apnea-hypopnea events was not observed. Body mass index was lower than 18 in 9 cases (52.9%) and 7 children (41.1%) presented a history of abnormal behavior during sleep. In most cases oxygen desaturation and reduction of sleep efficiency were mild. Sleep architecture was similar to the young adult pattern. Seven children (41.1%) presented pH monitoring values below 4 during more than 10% of total sleep time. pH monitoring values were correlated to emotional distress (p=0.008) and to daytime problems (p=0.03) as evaluated by the OSA-18.
Conclusions:
GER is frequent and should be assessed in children from 6 to 12 years with OSAS. Emotional distress and daytime problems are correlated to increased GER severity.
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