Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

MAPK-activated protein kinase 2 orchestrates memory T-cell inflation in cytomegalovirus infection.

Journal of immunology (Baltimore, Md. : 1950)·2026

Same author

IDH1-R132H enhances oncolytic HSV-1 therapy by facilitating viral entry and immune activation in glioma.

Nature communications·2026

Same author

A Legacy of Mentorship: A Tribute to Lewis Cantley.

Cancer discovery·2026

Same author

MAPKAP Kinase 2 Orchestrates Memory T Cell Inflation in Cytomegalovirus Infection.

bioRxiv : the preprint server for biology·2026

Same author

A simple circuit to sustain intact tumor microenvironments for complex drug interrogations.

bioRxiv : the preprint server for biology·2025

Same author

A rebrand for proteasome inhibition in solid tumors via continuous hepatic artery infusion.

JCI insight·2025

Same journal

ZNRF3 and RNF43 are active monomeric E3 ubiquitin ligases that self-associate.

Science signaling·2026

Same journal

Allosteric ligands with distinct properties uncover tissue-specific physiological regulation mediated by free fatty acid receptor 2.

Science signaling·2026

Same journal

Diacylglycerol kinase ζ in B lymphocytes supports CD40-mediated immune synapse formation, mTORC1 signaling, and plasma cell fate.

Science signaling·2026

Same journal

The APC/C adaptor Cdh1 stabilizes STING to potentiate innate immune activation in renal cell carcinoma.

Science signaling·2026

Same journal

Fattening mother's milk with oxytocin.

Science signaling·2026

Same journal

Virion display reveals MD-1 as an endogenous agonist for the orphan receptor GPRC5B.

Science signaling·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 26, 2026

Performing Custom MicroRNA Microarray Experiments

Performing Custom MicroRNA Microarray Experiments

Published on: October 28, 2011

Beyond microarrays.

Michael B Yaffe¹

¹American Association for the Advancement of Science, 1200 New York Avenue N.W., Washington, DC 20005, USA. myaffe@aaas.org

Science Signaling

|December 26, 2008

Summary

This summary is machine-generated.

Microarray analysis of RNA expression offers new ways to study gene expression. However, challenges persist in data analysis and interpretation for biological insights.

More Related Videos

Snap Chip for Cross-reactivity-free and Spotter-free Multiplexed Sandwich Immunoassays

Snap Chip for Cross-reactivity-free and Spotter-free Multiplexed Sandwich Immunoassays

Published on: November 13, 2017

DNA Microarrays: Sample Quality Control, Array Hybridization and Scanning

DNA Microarrays: Sample Quality Control, Array Hybridization and Scanning

Published on: March 15, 2011

Related Experiment Videos

Last Updated: Jun 26, 2026

Performing Custom MicroRNA Microarray Experiments

Performing Custom MicroRNA Microarray Experiments

Published on: October 28, 2011

Snap Chip for Cross-reactivity-free and Spotter-free Multiplexed Sandwich Immunoassays

Snap Chip for Cross-reactivity-free and Spotter-free Multiplexed Sandwich Immunoassays

Published on: November 13, 2017

DNA Microarrays: Sample Quality Control, Array Hybridization and Scanning

DNA Microarrays: Sample Quality Control, Array Hybridization and Scanning

Published on: March 15, 2011

Area of Science:

Genomics
Molecular Biology
Bioinformatics

Background:

Microarray technology has revolutionized gene expression analysis.
Current methods for analyzing RNA expression data present significant challenges.

Purpose of the Study:

To address the difficulties in interpreting complex gene expression data from microarrays.
To explore methods for gaining biologically meaningful mechanistic insights from RNA expression assays.

Main Methods:

Utilizing advanced statistical techniques for microarray data analysis.
Developing computational approaches for interpreting gene expression patterns.

Main Results:

Identified key challenges in current RNA expression data analysis pipelines.
Demonstrated potential strategies for enhancing the biological interpretation of microarray results.

Conclusions:

Further development in data analysis is crucial for unlocking the full potential of microarray technology.
Improved interpretation methods will facilitate deeper understanding of gene regulatory mechanisms.