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Unbiased Deep Sequencing of RNA Viruses from Clinical Samples
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Unbiased Deep Sequencing of RNA Viruses from Clinical Samples

Published on: July 2, 2016

Simple, sensitive, and swift sequencing of complete H5N1 avian influenza virus genomes

Dirk Höper1, Bernd Hoffmann, Martin Beer

  • 1Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Südufer 10, Greifswald-Insel Riems 17493, Germany.

Journal of Clinical Microbiology
|December 26, 2008
PubMed

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Viral Mutations00:36

Viral Mutations

A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material for adaptive...