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Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
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Updated: Jun 26, 2026

Physiological Recordings of High and Low Output NMJs on the Crayfish Leg Extensor Muscle
10:00

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Published on: November 17, 2010

Control of presynaptic function by a persistent Na(+) current.

Hai Huang1, Laurence O Trussell

  • 1Oregon Hearing Research Center and Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA.

Neuron
|December 27, 2008
PubMed
Summary
This summary is machine-generated.

Researchers discovered a significant persistent sodium current (Na+) in nerve terminals, crucial for regulating electrical activity and neurotransmitter release. This finding sheds light on the fundamental mechanisms controlling nerve signal transmission and synaptic function.

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Presynaptic Dopamine Dynamics in Striatal Brain Slices with Fast-scan Cyclic Voltammetry
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Related Experiment Videos

Last Updated: Jun 26, 2026

Physiological Recordings of High and Low Output NMJs on the Crayfish Leg Extensor Muscle
10:00

Physiological Recordings of High and Low Output NMJs on the Crayfish Leg Extensor Muscle

Published on: November 17, 2010

Acute Dissociation of Lamprey Reticulospinal Axons to Enable Recording from the Release Face Membrane of Individual Functional Presynaptic Terminals
12:01

Acute Dissociation of Lamprey Reticulospinal Axons to Enable Recording from the Release Face Membrane of Individual Functional Presynaptic Terminals

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Presynaptic Dopamine Dynamics in Striatal Brain Slices with Fast-scan Cyclic Voltammetry
08:49

Presynaptic Dopamine Dynamics in Striatal Brain Slices with Fast-scan Cyclic Voltammetry

Published on: January 12, 2012

Area of Science:

  • Neuroscience
  • Cellular Electrophysiology

Background:

  • Limited understanding of ion channels governing nerve terminal subthreshold properties.
  • Nerve terminals possess unique electrical characteristics influencing synaptic transmission.

Purpose of the Study:

  • To investigate ion channels regulating graded, subthreshold properties of nerve terminals.
  • To characterize a novel presynaptic persistent sodium current (Na+) in the calyx of Held.

Main Methods:

  • Electrophysiological recordings from the calyx of Held nerve terminal.
  • Voltage-clamp and current-clamp techniques to analyze ion channel activity.
  • Pharmacological manipulation of glycine receptors.

Main Results:

  • Identified a large presynaptic persistent Na+ current with hyperpolarized activation.
  • This Na+ current dictates the resting potential and conductance of the nerve terminal.
  • Activation of this Na+ current is essential for the response to presynaptic glycine receptor activation.

Conclusions:

  • Presynaptic persistent Na+ current plays a critical role in nerve terminal excitability and function.
  • This Na+ current influences both the initiation and modulation of neurotransmitter exocytosis.
  • Na+ channels are key regulators of presynaptic voltage, impacting synaptic transmission.