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Updated: Jun 26, 2026

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
Published on: August 2, 2017
Correlation of glucose concentrations in maternal serum and amniotic fluid in high-risk pregnancies
Sara G Rinala1, Vicki L Dryfhout, Donna S Lambers
1Department of Obstetrics and Gynecology, Good Samaritan Hospital, Cincinnati, OH 45220, USA.
Objective:
We sought to determine whether a correlation exists between maternal serum glucose and amniotic fluid glucose in high-risk pregnancies.
Study Design:
We conducted a prospective cross-sectional study of 60 patients, between 15 and 38 weeks' gestation, undergoing amniocentesis between March 2006 and April 2007. Participants underwent amniocentesis with evaluation of amniotic fluid glucose and maternal finger stick glucose. Data were collected on maternal demographics, gestational age, presence of diabetes or chorioamnionitis, use of betamethasone, and body mass index. Statistical analyses included Spearman rho correlations.
Results:
A positive correlation was found between maternal serum glucose and amniotic fluid glucose (r = 0.401, P < .01), and amniotic fluid index and diabetes (r = 0.367, P < .05). An inverse correlation was found between amniotic fluid glucose and chorioamnionitis (r = -0.499, P < .01).
Conclusion:
Maternal hyperglycemia directly influences amniotic fluid glucose levels and may result in an elevated amniotic fluid glucose value.
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