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A Controlled Mouse Model for Neonatal Polymicrobial Sepsis
14:54

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis

Published on: January 27, 2019

[Mortality rates in pediatric septic shock secondary to community-acquired infection: about 70 cases]

K Menif1, A Khaldi, A Bouziri

  • 1Service de réanimation pédiatrique polyvalente, hôpital d'enfants de Tunis, place Bab-Saadoun-Jebbari, Tunis, Tunisie. menifk@yahoo.fr

Medecine Et Maladies Infectieuses
|December 27, 2008
PubMed

Insights

The mortality rate for pediatric septic shock from community-acquired infections was 45.7%. Key risk factors for mortality included multiple organ failure, high fluid resuscitation volumes, and extensive vasoactive drug use.

Area of Science:

  • Pediatric critical care medicine
  • Infectious diseases
  • Epidemiology

Context:

  • Septic shock in children is a life-threatening condition.
  • Community-acquired infections are a common cause of pediatric sepsis.
  • Understanding mortality factors is crucial for improving outcomes.

Purpose:

  • To determine the mortality rate in children with septic shock due to community-acquired infections.
  • To identify independent risk factors associated with mortality in this population.

Summary:

  • A retrospective analysis of 70 pediatric patients admitted to the ICU for septic shock revealed a mortality rate of 45.7%.
  • Multivisceral failure, significant fluid resuscitation on day two, and the need for multiple vasoactive drugs were identified as independent predictors of mortality.
  • The average age was 3.8 years, with a high incidence of multivisceral failure (98.6%).

Impact:

  • Identifies critical risk factors to guide clinical management and resource allocation.
  • Highlights the severity of pediatric septic shock and the need for timely and aggressive intervention.
  • Provides data to inform guidelines for the treatment of pediatric septic shock.
Abstract

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