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Updated: Jun 26, 2026
Quantitative Measure of Lung Structure and Function Obtained from Hyperpolarized Xenon Spectroscopy
Published on: November 10, 2023
A simple method for quantitative measurement and analysis of hyperpolarized (129)Xe uptake dynamics in mouse brain
Atsuomi Kimura1, Hirohiko Imai, Tetsuya Wakayama
1Division of Medical Physics and Engineering, Graduate School of Medicine, Osaka University. Osaka, Japan. kimura@sahs.med.osaka-u.ac.jp
Abstract:
We established a simple method for measuring and quantifying uptake dynamics of hyperpolarized (HP) (129)Xe in mouse brain, which includes application of a saturation recovery pulse sequence under controlled flow of HP (129)Xe. The technique allows pursuit of the time-dependent change in (129)Xe nuclear magnetic resonance signal in the uptake process without effect from radiofrequency destruction of the polarization and the dynamics in mouse lung. The uptake behavior is well described by a simple model that depends only on a decay rate constant comprising cerebral blood flow and the longitudinal relaxation rate of HP (129)Xe in the brain tissue. The improved analysis enabled precise determination of the decay rate constant as 0.107+/-0.013 s(-1) (+/-standard deviation, n=5), leading to estimation of longitudinal relaxation time, T(1i), as 15.3+/-3.5 s.
