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Related Concept Videos

Tonsillitis I: Introduction01:30

Tonsillitis I: Introduction

Tonsillitis is inflammation of the tonsils, which are two lymphoid tissue masses at the back of the throat. This condition can cause discomfort and irritation in the throat.
Etiology
Three primary contributing factors have been identified.
Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Tonsillitis II: Management01:26

Tonsillitis II: Management

This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
Chronic Pharyngitis01:23

Chronic Pharyngitis

Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...

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Related Experiment Video

Updated: Jun 26, 2026

Isolation of Tonsillar Mononuclear Cells to Study Ex Vivo Innate Immune Responses in a Human Mucosal Lymphoid Tissue
07:38

Isolation of Tonsillar Mononuclear Cells to Study Ex Vivo Innate Immune Responses in a Human Mucosal Lymphoid Tissue

Published on: June 14, 2020

[Localized amyloidosis in the tonsil].

Takahiro Tsuji1, Hiroshi Yamasaki, Hideyuki Sasho

  • 1Division of Hematology and Oncology, Kumamoto City Hospital, Japan.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|December 27, 2008
PubMed
Summary

This study reports an extremely rare case of amyloidosis localized in the tonsil. The condition involved amyloid deposits and a foreign body giant cell reaction, with no signs of multiple myeloma.

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Performing and Processing FNA of Anterior Fat Pad for Amyloid
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Related Experiment Videos

Last Updated: Jun 26, 2026

Isolation of Tonsillar Mononuclear Cells to Study Ex Vivo Innate Immune Responses in a Human Mucosal Lymphoid Tissue
07:38

Isolation of Tonsillar Mononuclear Cells to Study Ex Vivo Innate Immune Responses in a Human Mucosal Lymphoid Tissue

Published on: June 14, 2020

Efficient Isolation Protocol for B and T Lymphocytes from Human Palatine Tonsils
08:09

Efficient Isolation Protocol for B and T Lymphocytes from Human Palatine Tonsils

Published on: November 16, 2015

Performing and Processing FNA of Anterior Fat Pad for Amyloid
09:41

Performing and Processing FNA of Anterior Fat Pad for Amyloid

Published on: October 30, 2010

Area of Science:

  • Otorhinolaryngology
  • Pathology
  • Immunology

Background:

  • Amyloidosis is a rare condition characterized by the deposition of amyloid proteins in various organs.
  • Localized amyloidosis, particularly in the tonsils, is exceptionally uncommon.

Observation:

  • A 71-year-old male presented with right tonsil enlargement.
  • Histological examination revealed amyloid deposits obliterating tonsillar structures.
  • A foreign body giant cell reaction and plasma cells containing light chain lambda were observed.

Findings:

  • The patient had no detectable M-proteins or Bence Jones proteins.
  • Bone marrow examination ruled out multiple myeloma.
  • Amyloidosis was localized exclusively to the tonsil, with other organs unaffected.

Implications:

  • This case highlights the importance of considering localized amyloidosis in the differential diagnosis of tonsillar enlargement.
  • Further research into the pathogenesis and diagnostic criteria for tonsillar amyloidosis is warranted.
  • Understanding this rare presentation can improve diagnostic accuracy and patient management in head and neck pathology.