Related Experiment Video
Updated: Jun 26, 2026
Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging
Published on: August 1, 2017
Humanized mouse models to study the human haematopoietic stem cell compartment
1Haematopoietic Stem Cell Laboratory, Cancer Research UK, London Research Institute, London, UK.
The ideal way to assess hematopoietic stem cells is to observe their growth in the endogenous microenvironment where they would receive the appropriate signals. With colonies of inbred mice, it is possible to myeloablate recipients and transplant hematopoietic cells from genetically similar mice and observe the growth of primitive hematopoietic cells in their endogenous environment for a significant proportion (10 months) of an organisms lifespan (29 months average). It is not possible to perform these experiments in humans, but xenotransplantation mouse models provide the closest paradigm for the human hematopoietic environment at the present time.
The ideal way to assess hematopoietic stem cells is to observe their growth in the endogenous microenvironment where they would receive the appropriate signals. With colonies of inbred mice, it is possible to myeloablate recipients and transplant hematopoietic cells from genetically similar mice and observe the growth of primitive hematopoietic cells in their endogenous environment for a significant proportion (10 months) of an organisms lifespan (29 months average). It is not possible to perform these experiments in humans, but xenotransplantation mouse models provide the closest paradigm for the human hematopoietic environment at the present time.
