Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gastroesophageal Reflux Disease I: Meaning and Pathophysiology01:29

Gastroesophageal Reflux Disease I: Meaning and Pathophysiology

Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...
Gastroesophageal Reflux Disease01:25

Gastroesophageal Reflux Disease

Gastroesophageal reflux disease (GERD) is the backward flow of stomach contents (acid, pepsin, or bile) into the esophagus, causing mucosal inflammation known as esophagitis. It results from failure of antireflux mechanisms, mainly the lower esophageal sphincter (LES), influenced by mechanical and physiological factors.Etiology and Risk FactorsGERD develops when LES function is weakened or when intra-abdominal pressure increases. Risk factors include aging, obesity, and sliding hiatal hernia,...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Machine Learning Model for Predicting Posthepatectomy Liver Failure After Hepatectomy With Extrahepatic Bile Duct Resection for Perihilar Cholangiocarcinoma: With and Without Indocyanine Green.

Annals of gastroenterological surgery·2026
Same author

Surgical Resection for Colorectal Liver Metastasis in Elderly Patients Aged ≥ 80: A Retrospective Nationwide Cohort Survey in Japan With Propensity Score Matching.

Annals of gastroenterological surgery·2026
Same author

Laparoscopic hepatectomy is feasible for patients diagnosed with hepatocellular carcinoma and cirrhotic liver.

World journal of gastrointestinal surgery·2026
Same author

Clinical Outcomes of Fontan-Associated Hepatocellular Carcinoma: a Single-Center Retrospective Study.

Journal of gastroenterology and hepatology·2026
Same author

[A Case of Oligometastatic Recurrent Colorectal Liver Metastasis Effectively Treated with Stereotactic Body Radiation Therapy].

Gan to kagaku ryoho. Cancer & chemotherapy·2026
Same author

Laparoscopic versus open liver resection in patients aged at least 80 years: retrospective propensity score-matched cohort study.

BJS open·2025

Related Experiment Video

Updated: Jun 26, 2026

Surgical Models of Gastroesophageal Reflux with Mice
05:19

Surgical Models of Gastroesophageal Reflux with Mice

Published on: August 25, 2015

Biliopancreatic reflux-pathophysiology and clinical implications.

Terumi Kamisawa1, Masanao Kurata, Goro Honda

  • 1Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Bunkyo-ku, Tokyo, Japan. kamisawa@cick.jp

Journal of Hepato-Biliary-Pancreatic Surgery
|December 27, 2008
PubMed
Summary

Pancreaticobiliary maljunction allows two-way reflux between ducts, causing biliary and pancreatic issues. This reflux, particularly biliopancreatic reflux, is linked to acute pancreatitis, even without obstruction.

Related Experiment Videos

Last Updated: Jun 26, 2026

Surgical Models of Gastroesophageal Reflux with Mice
05:19

Surgical Models of Gastroesophageal Reflux with Mice

Published on: August 25, 2015

Area of Science:

  • Gastroenterology
  • Surgical Anatomy
  • Pathophysiology

Background:

  • The common bile duct and main pancreatic duct often form a common channel into the duodenum.
  • The sphincter of Oddi regulates biliary and pancreatic outflow but is functionally ineffective in pancreaticobiliary maljunction.
  • Pancreaticobiliary maljunction leads to bidirectional reflux (pancreatobiliary and biliopancreatic), causing pathological conditions.

Purpose of the Study:

  • To investigate the implications of pancreaticobiliary maljunction and associated reflux.
  • To explore the relationship between biliopancreatic reflux and the development of acute pancreatitis.

Main Methods:

  • Confirmation of biliopancreatic reflux through operative/postoperative T-tube cholangiography.
  • Utilizing CT combined with drip infusion cholangiography.
  • Histological detection of gallbladder cancer cells in the main pancreatic duct.
  • Observing bile reflux on the pancreas's cut surface.

Main Results:

  • Biliopancreatic reflux is frequently observed in patients with a long common channel.
  • Obstruction of a long common channel facilitates bile flow into the pancreas.
  • Biliopancreatic reflux can induce acute pancreatitis, irrespective of obstruction.

Conclusions:

  • Pancreaticobiliary maljunction results in functionally significant reflux.
  • Biliopancreatic reflux is a contributing factor to acute pancreatitis.
  • Further research is needed to fully elucidate the prevalence and pathophysiology of biliopancreatic reflux.