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Updated: Jun 26, 2026
10:52
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
Diffuse gastrointestinal involvement of mantle cell lymphoma
Murat Meral1, Mustafa Demirpençe, Can Gönen
1Department of Gastroenterology, Dokuz Eylul University Medical Faculty, Izmir, Turkey. murat.meral@deu.edu.tr
Summary
This study details a rare case of gastrointestinal mantle cell lymphoma presenting as multiple lymphomatous polyposis. Early endoscopic detection and combination chemotherapy led to successful patient treatment.
Area of Science:
- Gastroenterology
- Hematology
- Oncology
Background:
- Extranodal non-Hodgkin lymphomas predominantly occur in the gastrointestinal tract.
- Mantle cell lymphoma (MCL) is a type of non-Hodgkin lymphoma.
- Multiple lymphomatous polyposis (MLP) is a rare gastrointestinal manifestation of MCL.
Observation:
- A 68-year-old patient presented with symptoms including intermittent diarrhea, weight loss, hematochezia, and fatigue.
- Endoscopic evaluation revealed multiple polypoid lesions throughout the gastrointestinal tract, consistent with MLP.
- Biopsy specimens from the colon, small intestine, and stomach confirmed gastrointestinal MCL.
Findings:
- The patient was diagnosed with multiple lymphomatous polyposis, a rare form of gastrointestinal mantle cell lymphoma.
- Histopathological and immunohistochemical analyses confirmed the diagnosis.
- The condition accounted for 2% of primary gastrointestinal lymphomas.
Implications:
- This case highlights the importance of endoscopic evaluation in diagnosing rare gastrointestinal lymphomas.
- Prompt diagnosis and combination chemotherapy can lead to successful treatment outcomes for gastrointestinal MCL.
- Further research into MLP may improve understanding and management of this rare entity.
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