Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Global Climate Change01:50

Global Climate Change

28.8K
Throughout its ~4.5 billion year history, the Earth has experienced periods of warming and cooling. However, the current drastic increase in global temperatures is well outside of the Earth’s cyclic norms, and evidence for human-caused global climate change is compelling. Paleoclimatology, the study of ancient climate conditions, provides ample evidence for human-caused global climate change by comparing recent conditions with those in the past.
28.8K
Empathy02:34

Empathy

10.1K
Some researchers suggest that altruism operates on empathy. Empathy is the capacity to understand another person’s perspective, to feel what he or she feels. An empathetic person makes an emotional connection with others and feels compelled to help (Batson, 1991). Empathy can be expressed in several ways, including cognitive, affective, and motor. 
10.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The dosage and administration of long-term intrathecal baclofen therapy for severe spasticity of spinal origin.

Spinal cord·2018
Same author

Sequential neurological improvements after conservative treatment in patients with complete motor paralysis caused by cervical spinal cord injury without bone and disc injury.

Journal of neurosurgery. Spine·2018
Same author

Sensitivity and specificity of the 'knee-up test' for estimation of the American Spinal Injury Association Impairment Scale in patients with acute motor incomplete cervical spinal cord injury.

Spinal cord·2017
Same author

A Safe Surgical Procedure for Old Distractive Flexion Injuries of the Subaxial Cervical Spine.

Asian spine journal·2017
Same author

Can the acute magnetic resonance imaging features reflect neurologic prognosis in patients with cervical spinal cord injury?

The spine journal : official journal of the North American Spine Society·2017
Same author

Normative data for parameters of sagittal spinal alignment in healthy subjects: an analysis of gender specific differences and changes with aging in 626 asymptomatic individuals.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2016

Related Experiment Video

Updated: Jan 24, 2026

A Modified Method for Intrathecal Catheterization in Rats
11:15

A Modified Method for Intrathecal Catheterization in Rats

Published on: February 14, 2025

2.9K

[Intrathecal baclofen for severe spasticity].

Takayoshi Ueta1

  • 1Department of Orthopedics, Spinal Injuries Center, Iizuka, Fukuoka 820-0053, Japan.

Brain and Nerve = Shinkei Kenkyu No Shinpo
|December 30, 2008
PubMed
Summary
This summary is machine-generated.

Intrathecal baclofen (ITB) infusion effectively reduces spasticity in patients with brain and spinal cord injuries. This treatment improves daily activities and mobility, with high patient satisfaction despite rare complications.

More Related Videos

Direct Intrathecal Injection of Recombinant Adeno-associated Viruses in Adult Mice
08:17

Direct Intrathecal Injection of Recombinant Adeno-associated Viruses in Adult Mice

Published on: February 15, 2019

39.3K
Breathing-controlled Electrical Stimulation BreEStim for Management of Neuropathic Pain and Spasticity
11:34

Breathing-controlled Electrical Stimulation BreEStim for Management of Neuropathic Pain and Spasticity

Published on: January 10, 2013

23.6K

Related Experiment Videos

Last Updated: Jan 24, 2026

A Modified Method for Intrathecal Catheterization in Rats
11:15

A Modified Method for Intrathecal Catheterization in Rats

Published on: February 14, 2025

2.9K
Direct Intrathecal Injection of Recombinant Adeno-associated Viruses in Adult Mice
08:17

Direct Intrathecal Injection of Recombinant Adeno-associated Viruses in Adult Mice

Published on: February 15, 2019

39.3K
Breathing-controlled Electrical Stimulation BreEStim for Management of Neuropathic Pain and Spasticity
11:34

Breathing-controlled Electrical Stimulation BreEStim for Management of Neuropathic Pain and Spasticity

Published on: January 10, 2013

23.6K

Area of Science:

  • Neuroscience
  • Pharmacology
  • Neurosurgery

Context:

  • Spasticity is a common and debilitating symptom following brain or spinal cord injuries.
  • Severe spasticity significantly impairs patients' ability to perform activities of daily living (ADLs).
  • Oral baclofen has limited efficacy due to the blood-brain barrier (BBB), hindering spinal cord drug concentrations.

Purpose:

  • To evaluate the efficacy and patient satisfaction of intrathecal baclofen (ITB) infusion for managing severe spasticity.
  • To assess the long-term outcomes and potential complications associated with ITB pump implantation.

Summary:

  • Intrathecal baclofen (ITB) administration bypasses the BBB, delivering the neuroinhibitor directly to the spinal cord.
  • Since its 2006 approval in Japan, ITB treatment has been administered to 40 patients, with 22 receiving pump implants.
  • Patients with ITB pump implants reported high satisfaction due to significant spasticity reduction, improved ADLs, and enhanced mobility.

Impact:

  • ITB treatment offers a highly effective solution for severe spasticity, significantly improving quality of life for patients with neurological injuries.
  • The study highlights the safety and efficacy of ITB, with successful re-implantation in cases of device-related complications.
  • ITB therapy demonstrates a positive impact on functional independence and mobility in individuals with spinal cord and brain injuries.