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[Anticipation in bipolar disorder: A comparison between two generations]
Zeki Yüncü1, Sermin Kesebir, Fisun Akdeniz
1Ege U Cocuk, Ergen Alkol-Madde Bağimlilği Araştirma ve Uygulama Merkezi, Izmir. drzekiyuncu@hotmail.com
Turk Psikiyatri Dergisi = Turkish Journal of Psychiatry
|December 30, 2008
Summary
Genetic anticipation, characterized by earlier onset and increased severity, was observed in bipolar disorder (BP) type 1. Psychotic features in parents may indicate anticipation in offspring.
Area of Science:
- Neuroscience
- Genetics
- Psychiatry
Context:
- Anticipation is a genetic phenomenon seen in neurodegenerative diseases.
- It is hypothesized to occur in bipolar disorder (BP).
Purpose:
- To assess anticipation in bipolar disorder type 1 (BP type 1).
- To analyze clinical characteristics and prognoses in successive generations of BP type 1 patients.
Summary:
- Age at onset for BP type 1 was significantly earlier in the second generation (s2) compared to the first generation (s1).
- A negative correlation was found between generations regarding age at onset.
- The frequency of episodes was higher in the second generation, and psychotic features in parents correlated with those in offspring.
Impact:
- This study provides evidence for genetic anticipation in bipolar disorder type 1.
- Psychotic features may serve as a potential marker for anticipating inheritance in BP type 1.
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