The prevalence of methicillin-resistant Staphylococcus aureus on inanimate objects in an Urban Emergency Department

Jonathan Kei1, John R Richards

  • 1Department of Emergency Medicine, University of California at Davis Medical Center, Sacramento, California 95817, USA.

Abstract

Insights

Methicillin-resistant Staphylococcus aureus (MRSA) rarely spreads via inanimate objects in emergency departments (EDs). A study found MRSA on only one surface, suggesting routine cleaning should encompass all staff-used areas.

Area of Science:

  • Infectious Diseases
  • Hospital Epidemiology
  • Microbiology

Background:

  • Rising prevalence of hospital-acquired and community-associated methicillin-resistant Staphylococcus aureus (MRSA) infections.
  • Both MRSA strains are frequently encountered in emergency department (ED) patients.

Purpose of the Study:

  • To identify common objects within the ED environment that may contribute to MRSA transmission.
  • Investigate the potential role of fomites in MRSA spread within healthcare settings.

Main Methods:

  • Cross-sectional prevalence study conducted in a large urban ED.
  • Culture swabs collected from 20 distinct objects (e.g., computers, phones, keypads, probes) over four months.
  • Each object sampled twice, with positive MRSA samples undergoing susceptibility testing.

Main Results:

  • MRSA was detected in only one of 40 samples, yielding a prevalence of 2.5%.
  • The sole positive sample originated from an ambulance bay security door keypad.
  • The isolated MRSA strain exhibited resistance to clindamycin, erythromycin, oxacillin, and penicillin.

Conclusions:

  • Inanimate objects in the ED appear to be a minor reservoir for MRSA.
  • Effective MRSA control necessitates comprehensive cleaning protocols covering all areas of staff activity, including those outside the ED.

Related Concept Videos

Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies. Common...
Cleaning, Sterilization, and Disinfection01:30

Cleaning, Sterilization, and Disinfection

Cleaning, disinfection, and sterilization are the methods that help to break the infection chain and prevent disease.
Cleaning
The cleaning process usually involves using water with detergents or enzymatic cleaner and removing foreign material from objects and surfaces, including organic material such as body fluids or inorganic material like soil. Cleaning is performed before high-level disinfection and sterilization because foreign materials on the cover of the devices interfere with process...