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Published on: October 18, 2017
Non-lethal Candida albicans cph1/cph1 efg1/efg1 mutant partially protects mice from systemic infections by lethal
Yun-Liang Yang1, Chih-Wei Wang, Chiung-Tong Chen
1Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan.
Abstract:
Although Candida albicans cph1/cph1 efg1/efg1 mutant cells are not lethal to mice, they proliferated in infected mice instead of simply being cleared by the host immune system. Here, we have shown that the cph1/cph1 efg1/efg1 mutant partially protects mice from systemic infections by the lethal wild-type Candida albicans cells. Our results further indicate that a second dose of the cph1/cph1 efg1/efg1 mutant did not boost the degree of protection.
