Related Experiment Video
Updated: Jun 26, 2026
12:31
In Vivo Modeling of the Morbid Human Genome using Danio rerio
Published on: August 24, 2013
Ductal plate malformation in a nonhuman primate
S Wallace1, T Blanchard, L Rabin
1Armed Forces Institute of Pathology, Washington, DC, USA. shannon.m.wallace@us.army.mil
Veterinary Pathology
|December 30, 2008
Summary
This study reports the first case of hepatic ductal plate malformation in a nonhuman primate, specifically an African Green monkey. This rare liver condition involves abnormal bile duct development and collagen deposition.
Area of Science:
- Veterinary Pathology
- Comparative Pathology
- Primate Medicine
Background:
- Hepatic ductal plate malformation is a rare congenital liver disorder characterized by abnormal development of intrahepatic bile ducts.
- While documented in some domestic animals, cases in nonhuman primates are exceptionally scarce in scientific literature.
Observation:
- Necropsy of a 6-year-old male African Green monkey revealed multifocal pale, white to tan lesions (1-2 cm) in the liver.
- Microscopic examination showed numerous spindle cells within broad, interconnecting collagen bands, connecting portal areas.
Findings:
- The observed liver pathology was diagnosed as hepatic ductal plate malformation, closely resembling congenital hepatic fibrosis with von Meyenburg complexes.
- This represents the first documented instance of this condition in a nonhuman primate.
Implications:
- This case expands the understanding of hepatic ductal plate malformation in a comparative veterinary context.
- Highlights the importance of considering rare congenital liver diseases in nonhuman primate research models.
- Contributes to the limited knowledge base of liver pathology in African Green monkeys.
