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Updated: Jun 26, 2026

Synthesis, Hemoglobin Encapsulation and Biorthogonal PEGylation in Hierarchically Porous UiO-66 Nanoparticles for Oxygen Delivery Applications
Published on: May 8, 2026
HBOC-201: the multi-purpose oxygen therapeutic
Gregory P Dubé1, Pascal Vranckx, A Gerson Greenburg
1Cardiovascular Research, Biopure Corporation, Cambridge, Massachusetts 02141, USA. gdube@biopure.com
Abstract:
Clinical and preclinical studies have revealed a diverse array of indications in which the effectiveness of HBOC-201 has been demonstrated or appears likely. Included among these are indications involving cardiac and peripheral ischaemia in which this oxygen therapeutic may prove to be an important tool in the armamentarium of the cardiologist and surgeon. Preclinical studies and clinical trials are under way to further delineate and optimise the role of HBOC-201 as an oxygen therapeutic in cardiovascular medicine.
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