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Updated: Jun 26, 2026
10:27
Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
Interstitial granulomatous dermatitis associated with darifenacin
Holly R Mason1, Jil K Swanson, Jonhan Ho
1Department of Dermatology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Journal of Drugs in Dermatology : JDD
|December 31, 2008
Summary
Interstitial granulomatous dermatitis, often linked to rheumatoid arthritis, can also be drug-induced. This report details a rare case of this skin condition developing in a patient taking darifenacin for overactive bladder.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Interstitial granulomatous dermatitis is a rare skin condition.
- It is frequently associated with rheumatoid arthritis (RA).
- Medications are also known triggers for this condition.
Observation:
- A case of IGD is described in a patient using darifenacin.
- Darifenacin is a muscarinic antagonist approved for overactive bladder.
- This represents a potential new drug association for IGD.
Findings:
- The patient developed interstitial granulomatous dermatitis.
- The onset of the skin condition was temporally related to darifenacin use.
- This suggests darifenacin as a potential causative agent.
Implications:
- Highlights the importance of considering drug-induced causes for IGD.
- Adds darifenacin to the list of potential medications implicated in IGD.
- May prompt further investigation into the dermatological side effects of muscarinic antagonists.
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