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[The involvement of the renin-angiotensin system (RAS) in cancerogenesis]

Kamila Domińska1, Agnieszka Lachowicz-Ochedalska

  • 1Departament of Comparative Endocrinology, Medical University of Lodz, 3 Sterlinga St., 91-425 Lodz, Poland. kamila-107107@wp.pl

Postepy Biochemii
|December 31, 2008
PubMed

Insights

Angiotensin II (Ang II), known for cardiovascular effects, also regulates cell processes crucial in cancer development. Targeting the renin-angiotensin system (RAS) offers a promising new strategy for cancer therapy.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Context:

  • The renin-angiotensin system (RAS) is traditionally linked to cardiovascular regulation and fluid balance.
  • Recent research reveals the broader roles of angiotensin II (Ang II) in cellular functions.
  • These functions include cell growth, proliferation, migration, apoptosis, inflammation, differentiation, and angiogenesis.

Purpose:

  • To review the multifaceted role of the RAS in tumor biology.
  • To explore the clinical potential of targeting the angiotensin system in cancer treatment.

Summary:

  • Angiotensin II (Ang II), a key peptide in the RAS, influences numerous cellular processes beyond its classical functions.
  • These Ang II-mediated cellular activities, such as proliferation and angiogenesis, are implicated in cancer development and progression.
  • This review consolidates current understanding of RAS involvement in various tumors.

Impact:

  • Highlights the potential of RAS-targeted therapies as a novel and promising strategy for cancer treatment.
  • Suggests that modulating the angiotensin system could offer new avenues for oncological interventions.
  • Emphasizes the expanding role of the RAS in cellular regulation and disease pathology.

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