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Pinching-off of Coated Vesicles

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Related Experiment Video

Updated: Jun 26, 2026

Obtention of Giant Unilamellar Hybrid Vesicles by Electroformation and Measurement of their Mechanical Properties by Micropipette Aspiration
09:29

Obtention of Giant Unilamellar Hybrid Vesicles by Electroformation and Measurement of their Mechanical Properties by Micropipette Aspiration

Published on: January 19, 2020

Adsorption-induced vesicle fission.

Feng-Ching Tsai1, Hsuan-Yi Chen

  • 1Department of Physics, Institute of Biophysics, and Center for Complex Systems, National Central University, Jhongli, 32001 Taiwan.

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
|December 31, 2008
PubMed
Summary
This summary is machine-generated.

This study presents a theoretical model for vesicle formation via particle aggregation on membranes. Vesicle fission is energetically favorable, with formation rates dependent on particle adsorption rates.

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A Photodynamic Approach to Study Function of Intracellular Vesicle Rupture
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A Photodynamic Approach to Study Function of Intracellular Vesicle Rupture

Published on: March 17, 2023

Area of Science:

  • Biophysics
  • Materials Science
  • Physical Chemistry

Background:

  • Particle adsorption and aggregation on membrane surfaces can drive membrane remodeling.
  • Vesicle formation is a critical process in cellular biology and nanotechnology.

Purpose of the Study:

  • To develop a theoretical model for vesicle fission induced by particle adsorption and aggregation.
  • To investigate the energetic favorability and kinetics of particle-induced vesicle formation.

Main Methods:

  • Theoretical modeling of particle-membrane interactions.
  • Analysis of adsorption, aggregation, and domain formation dynamics.
  • Calculation of energy barriers and vesicle formation rates.

Main Results:

  • Vesicle formation is energetically favored under typical experimental conditions.
  • An energy barrier for domain nucleation may exist at small particle numbers.
  • Vesicle formation rate depends on particle adsorption rate (jon), scaling linearly for high jon and quadratically for low jon.
  • Particle-rich domains grow independently, and domain densities are high for small and near-critical particle numbers.

Conclusions:

  • The theoretical model provides insights into particle-mediated vesicle fission.
  • Particle adsorption and aggregation offer a controllable mechanism for vesicle formation.
  • Understanding these dynamics is crucial for applications in drug delivery and synthetic biology.