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Myxotyrosides A and B, Unusual rhamnosides from Myxococcus sp
Birgit Ohlendorf1, Wolfram Lorenzen, Stefan Kehraus
1Institute of Pharmaceutical Biology, UniVersity of Bonn, Nussallee 6, D-53115 Bonn, Germany.
Abstract:
Myxobacteria are gliding bacteria of the delta-subdivision of the Proteobacteria and known for their unique biosynthetic capabilities. Two examples of a new class of metabolites, myxotyrosides A (1) and B (2), were isolated from a Myxococcus sp. The myxotyrosides have a tyrosine-derived core structure glycosylated with rhamnose and acylated with unusual fatty acids such as (Z)-15-methyl-2-hexadecenoic and (Z)-2-hexadecenoic acid. The fatty acid profile of the investigated Myxococcus sp. (strain 131) is that of a typical myxobacterium with a high similarity to those described for M. fulvus and M. xanthus, with significant concentrations of neither 15-methyl-2-hexadecenoic acid nor 2-hexadecenoic acid being detected.
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