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Updated: Jun 26, 2026

Isolation, Transfection, and Culture of Primary Human Monocytes
Published on: December 16, 2019
MicroRNA profile changes in human immunodeficiency virus type 1 (HIV-1) seropositive individuals
Laurent Houzet1, Man Lung Yeung, Valery de Lame
1Molecular Virology Section, Laboratory of Molecular Microbiology National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA. houzetl@niaid.nih.gov
Abstract:
MicroRNAs (miRNAs) play diverse roles in regulating cellular and developmental functions. We have profiled the miRNA expression in peripheral blood mononuclear cells from 36 HIV-1 seropositive individuals and 12 normal controls. The HIV-1-positive individuals were categorized operationally into four classes based on their CD4+ T-cell counts and their viral loads. We report that specific miRNA signatures can be observed for each of the four classes.

