Eosinophil-rich inflammatory response to FloSeal hemostatic matrix presenting as postoperative pelvic pain

Area of Science:

• Surgical innovation
• Biomaterials science
• Adverse event reporting

Background:

• FloSeal hemostatic matrix is widely used for intraoperative bleeding control.
• Its efficacy in various surgical settings is well-documented.
• Potential adverse effects require ongoing investigation.

Observation:

• Three patients presented with unusual postoperative complications after FloSeal use.
• These complications included excessive granulation tissue and fibrosis.
• The observed tissue reactions were linked to early pelvic pain.

Findings:

• The patients experienced a possible allergic response to FloSeal hemostatic matrix.
• Excessive granulation tissue and fibrosis were significant findings.
• This led to severe early postoperative pelvic pain necessitating re-operation.

Implications:

• This case series highlights potential, previously underreported adverse reactions to FloSeal.
• Clinicians should be vigilant for allergic responses and associated complications.
• Further research into the immunogenicity and long-term tissue effects of FloSeal is warranted.