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Updated: Jun 26, 2026

Pulse Wave Velocity Testing in the Baltimore Longitudinal Study of Aging

Pulse Wave Velocity Testing in the Baltimore Longitudinal Study of Aging

Published on: February 7, 2014

Decrease of brachial-ankle pulse wave velocity in female subclinical hypothyroid patients during normalization of

Toshiki Nagasaki¹, Masaaki Inaba, Shinsuke Yamada

¹Department of Metabolism, Endocrinology and Molecular Medicine, Internal Medicine, Osaka City University Graduate School of Medicine, Osaka-City, Japan.

European Journal of Endocrinology

|December 31, 2008

Summary

Treating subclinical hypothyroidism in women with Hashimoto's disease using levothyroxine normalized thyroid function and significantly reduced arterial stiffness, indicated by brachial-ankle pulse wave velocity (baPWV). This suggests a potential cardiovascular disease prevention strategy.

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Last Updated: Jun 26, 2026

Pulse Wave Velocity Testing in the Baltimore Longitudinal Study of Aging

Pulse Wave Velocity Testing in the Baltimore Longitudinal Study of Aging

Published on: February 7, 2014

Area of Science:

Endocrinology
Cardiovascular Medicine
Immunology

Background:

Subclinical hypothyroidism affects 5-15% of the population, particularly females, and may be linked to cardiovascular disease.
Arterial stiffening, measured by brachial-ankle pulse wave velocity (baPWV), is a predictor of cardiovascular events.
Previous studies showed increased baPWV in subclinical hypothyroidism without thyroiditis.

Purpose of the Study:

To assess changes in baPWV in female subclinical hypothyroidism patients with autoimmune chronic thyroiditis (Hashimoto's disease).
To evaluate the effect of levothyroxine (l-T(4)) replacement therapy on baPWV after restoring normal thyroid function.

Main Methods:

A randomized placebo-controlled study involving 95 female subclinical hypothyroid patients with Hashimoto's disease.
Measurement of baPWV before and after levothyroxine (l-T(4)) replacement therapy.
Comparison with 42 age-matched normal female subjects.

Main Results:

Baseline baPWV was significantly higher in subclinical hypothyroid patients compared to normal subjects.
Levothyroxine treatment led to a significant decrease in baPWV (from 1776.7+/-86.0 to 1674.3+/-79.2 cm/s, P=0.006) upon achieving euthyroidism.
No correlation was found between changes in baPWV and TSH levels; age and baseline pulse pressure showed a negative correlation but were not significant predictors in multiple regression analysis.

Conclusions:

Sustained normalization of thyroid function with levothyroxine therapy significantly reduces baPWV in female subclinical hypothyroid patients with Hashimoto's disease.
This suggests an improvement in arterial stiffening.
The findings imply a potential role in the prevention of cardiovascular disease.