Related Experiment Video
Updated: Jun 26, 2026

Randomized Controlled Trial to Study the Acute Effects of Strength Exercise on Insulin Sensitivity in Obese Adults
Published on: December 1, 2023
The effect of training volume on the acute response and adaptations to resistance training
Jason Brandenburg1, David Docherty
1Dept of Kinesiology and Physical Education, Northern Illinois University, DeKalb, IL 60115, USA.
Purpose:
To examine the acute response to 2 resistance-exercise protocols performed to repetition failure, but different in load configuration, and determine whether the acute response was related to strength increases after 8 weeks of training.
Methods:
Eighteen resistance-trained men completed a single session of 2 resistance-exercise protocols. The constant-load protocol (CL) required subjects to complete 3 sets of single-arm preacher curls (elbow flexion) to failure using a load of approximately 77% 1RM. The reduced-load protocol (RL) was similar, but training load was reduced for the second and third sets. Maximal isometric force (MVIC) and blood lactate were assessed preprotocol and postprotocol to determine the acute response. For the 8-week training phase, subjects (N = 12) were divided into 2 programs, each corresponding to 1 of the protocols. Strength was measured before and after training.
Results:
MVIC decreased from 106.2 +/- 13.8 to 84.3 +/- 12.1 N . m and from 109.1 +/- 14.7 to 82.5 +/- 13 N . m after the CL and RL protocols, respectively. The decrements in MVIC were significant (P < .001), with the decline after RL tending to be greater (P = .051). Postprotocol blood lactate concentrations after CL and RL were 3.4 +/- 1.1 and 4.1 +/- 1.3 mmol/L, respectively, with greater increases after RL (P = .036). Similar and significant 1RM strength increases were observed after both programs (from 20.7 +/- 2.7 to 23.3 +/- 3.5 kg after CL and from 22.4 +/- 2.9 to 25.5 +/- 3.2 kg after RL; P < .001).
Conclusion:
The similar increases in strength suggest that either the greater acute response to RL was not related to the increases in strength or a minimal (threshold) response was achieved during both programs.
Related Concept Videos
Exercise and Muscle Performance
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Exercise and Cardiovascular Response
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Regulation of Stroke Volume
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
Exercise and Cardiac Output
Sustained exercise increases the muscles' oxygen demand, which can be met...
Cardiac Output II: Effect of Stroke Volume on Cardiac Output
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...
Cellular Adaptation II: Hypertrophy

