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Updated: Jun 26, 2026
08:23
Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds
Published on: February 16, 2022
The effect of decrease in serum nitric oxide concentration on portal hemodynamics after Helicobacter pylori
Ender Serin1, M Ali Pourbagher, Yüksel Gümürdülü
1Department of Gastroenterology, Başkent University, School of Medicine, Ankara, Turkey. eserin67@yahoo.com
Summary
Eradicating Helicobacter pylori infection significantly lowered serum nitrate and nitrite levels in liver cirrhosis patients. This reduction may positively impact splanchnic hemodynamics, particularly in those with esophageal varices.
Area of Science:
- Gastroenterology
- Hepatology
- Infectious Diseases
Background:
- Helicobacter pylori (H. pylori) infection causes gastritis, increasing serum nitrate and nitrite.
- Splanchnic hemodynamics are linked to nitrate and nitrite levels.
- Portal hypertension is a complication of liver cirrhosis.
Purpose of the Study:
- To investigate the impact of H. pylori eradication therapy on portal hemodynamics.
- To assess changes in serum nitrate and nitrite levels post-treatment.
Main Methods:
- Nineteen patients with liver cirrhosis and H. pylori gastritis underwent eradication therapy.
- Doppler ultrasonography measured portal vein parameters.
- Serum nitrate and nitrite levels were analyzed before and after treatment.
Main Results:
- H. pylori eradication was achieved in 73.7% of patients.
- Significant reductions in inflammation, H. pylori density, and serum nitrate/nitrite were observed post-therapy.
- Patients with esophageal varices showed significant decreases in serum nitrate and nitrite.
Conclusions:
- H. pylori eradication therapy reduces serum nitrate and nitrite levels.
- This reduction may offer beneficial effects on portal hemodynamics, especially in patients with varices.
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