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Protein flexibility and metal coordination changes in DHAP-dependent aldolases

Aurora Jiménez1, Pere Clapés, Ramon Crehuet

  • 1Institut de Química Avançada de Catalunya IQAC-CSIC c/Jordi Girona 18-26, 08034, Barcelona, Catalonia, Spain.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|December 31, 2008
PubMed
Summary

Enzyme mobility influences active site chemistry and catalytic rates. Rhamnulose-1-phosphate aldolase (RhuA) and fuculose-1-phosphate aldolase (FucA) exhibit coupled domain movements and metal coordination, explaining their similar turnover rates.

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