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Related Experiment Videos

Intestinal permeability in patients with psoriasis.

P Humbert1, A Bidet, P Treffel

  • 1Department of Dermatology, Hôpital St Jacques, Besançon, France.

Journal of Dermatological Science
|July 1, 1991
PubMed
Summary

Psoriatic patients show significantly higher intestinal permeability compared to healthy individuals. This suggests that alterations in the small intestinal lining may contribute to the development of psoriasis.

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Area of Science:

  • Gastroenterology
  • Dermatology
  • Immunology

Background:

  • Emerging research suggests a link between gut health and psoriasis pathogenesis.
  • Intestinal structure and function are increasingly recognized as potential factors in inflammatory skin diseases.

Purpose of the Study:

  • To investigate and compare intestinal permeability in patients with psoriasis versus healthy controls.
  • To explore the potential role of altered gut barrier function in psoriasis.

Main Methods:

  • Employed the chromium-51 labeled ethylenediaminetetraacetic acid (51Cr-EDTA) absorption test.
  • Quantified 24-hour urinary excretion of 51Cr-EDTA in both psoriatic patients and healthy volunteers.
  • Included 15 psoriatic patients and 15 age- and sex-matched healthy controls.

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Main Results:

  • Psoriatic patients exhibited a significantly higher mean 24-hour 51Cr-EDTA urine excretion (2.46 +/- 0.81%) compared to healthy controls (1.95 +/- 0.36%).
  • Statistical analysis confirmed a significant difference (P < 0.05) in intestinal permeability between the two groups.
  • Results indicate increased intestinal permeability in individuals with psoriasis.

Conclusions:

  • The study demonstrates significantly elevated intestinal permeability in psoriatic patients.
  • These findings suggest that compromised small intestinal epithelial integrity may be implicated in the pathogenesis of psoriasis.
  • Further research into gut-epithelial interactions is warranted for psoriasis management.