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Should HLA-B*5701 screening be performed in every ethnic group before starting abacavir?
Wan Beom Park1, Pyoeng Gyun Choe, Kyoung-Ho Song
1Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Abstract:
Human leukocyte antigen allele (HLA)-B*5701 is associated with abacavir hypersensitivity. However, the carriage rate of HLA-B*5701 has rarely been studied in Asians. In 534 Korean patients with human immunodeficiency virus infection, HLA-B*5701 status was determined by polymerase chain reaction with HLA-B*5701-specific primers. No patients had the HLA-B*5701 allele (95% confidence interval, 0%-0.7%). This explains the paucity of immunologically confirmed cases of abacavir hypersensitivity in Koreans.
