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EPA Method 1615. Measurement of Enterovirus and Norovirus Occurrence in Water by Culture and RT-qPCR. Part III. Virus Detection by RT-qPCR
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Enterovirus 71 outbreak, Brunei.

Sazaly AbuBakar1, I-Ching Sam, Jaliha Yusof

  • 1Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia. sazaly@um.edu.my

Emerging Infectious Diseases
|January 1, 2009
PubMed
Summary
This summary is machine-generated.

Enterovirus 71 (EV71) outbreaks are common in the Asia-Pacific. A 2006 Brunei outbreak revealed a distinct EV71 lineage (subgenogroup B5), indicating rapid local spread.

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EPA Method 1615. Measurement of Enterovirus and Norovirus Occurrence in Water by Culture and RT-qPCR. Part III. Virus Detection by RT-qPCR
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Detection of Infectious Virus from Field-collected Mosquitoes by Vero Cell Culture Assay
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Detection of Infectious Virus from Field-collected Mosquitoes by Vero Cell Culture Assay

Published on: June 9, 2011

Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Background:

  • Enterovirus 71 (EV71) causes outbreaks in the Asia-Pacific.
  • EV71 is associated with severe neurologic complications and fatalities.
  • Brunei experienced its first major EV71 outbreak in 2006.

Purpose of the Study:

  • To characterize the EV71 strains involved in the 2006 Brunei outbreak.
  • To understand the genetic diversity and origin of these EV71 strains.

Main Methods:

  • Phylogenetic analysis of isolated EV71 strains.
  • Genotyping of EV71 subgenogroups.

Main Results:

  • The 2006 Brunei EV71 strains belonged to subgenogroup B5.
  • These strains formed a distinct lineage with low intra-lineage diversity.
  • This suggests a recent introduction and rapid dissemination within Brunei.

Conclusions:

  • The 2006 EV71 outbreak in Brunei was caused by a specific, recently introduced lineage (B5).
  • The low genetic diversity indicates rapid spread within the country.
  • Findings highlight the importance of molecular surveillance for emerging viral threats.