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Related Experiment Videos

Cell polarity: intrinsic or externally imposed?

M Bornens1

  • 1Centre de Genetique Moléculaire, Centre National de la Recherche Scientifique, Gif-sur-Yvette, France.

The New Biologist
|June 1, 1991
PubMed
Summary

Cell polarity is intrinsically maintained by the cytoskeleton, not solely externally imposed. Microtubules and microfilaments dynamically regulate cell shape and function.

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Area of Science:

  • Cell Biology
  • Cytoskeleton Dynamics
  • Cell Polarity

Background:

  • Cell polarity is fundamental to cell function and development.
  • Existing models propose external signals dictate cell polarity.
  • Recent data suggest intrinsic mechanisms maintain cell polarity.

Purpose of the Study:

  • To investigate whether cell polarity is an intrinsic property or externally imposed.
  • To explore the role of the cytoskeleton in maintaining cell polarity.
  • To understand the molecular mechanisms governing cell polarity.

Main Methods:

  • Review of experimental data from various systems.
  • Analysis of cytoskeletal dynamics, including microfilaments and microtubules.
  • Examination of the centrosome-microtubule complex's role.

Main Results:

  • Evidence supports intrinsic cell polarity maintained by dynamic cytoskeletal activity.
  • External signals modulate, rather than establish, polarity by acting on maintenance mechanisms.
  • Microtubules inhibit cytoplasmic myosin recruitment, and centrosomes contribute to polarity establishment.

Conclusions:

  • Cell polarity is an intrinsic property maintained by the cytoskeleton.
  • Understanding microtubule-microfilament interactions is key to cell polarity research.
  • The centrosome plays an active role in establishing cell polarity.

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