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Simple febrile seizures: are the AAP guidelines regarding lumbar puncture being followed?
Oranit Shaked1, Barbara M Garcia Peña, Marc Y R Linares
1Division of Emergency Medicine, Department of Pediatrics, Miami Children's Hospital, Miami, FL 33155, USA. oranit.shaked@gmail.com
Insights
Pediatricians are not consistently following guidelines for lumbar puncture (LP) in infants with febrile seizures. Current recommendations may need updating based on modern disease prevalence and causes.
Area of Science:
- Pediatrics
- Emergency Medicine
- Infectious Disease
Background:
- The American Academy of Pediatrics (AAP) issued guidelines in 1996 recommending lumbar puncture (LP) for infants under 12 months with a first febrile seizure.
- These recommendations aimed to diagnose meningitis in young children presenting with seizures.
Purpose of the Study:
- To evaluate adherence to AAP guidelines for LP in infants with febrile seizures.
- To determine the incidence of meningitis in children undergoing LP for febrile seizures.
- To assess the impact of patient age and antibiotic pretreatment on LP performance.
Main Methods:
- A retrospective chart review was conducted at Miami Children's Hospital.
- The study included 56 infants aged 6-12 months with a first simple febrile seizure.
- Data were collected between January 2001 and November 2005.
Main Results:
- Lumbar puncture was performed in 50% of eligible patients.
- No significant difference in LP performance was observed based on patient age or prior antibiotic use.
- No cases of meningitis were diagnosed in the study group, with all cerebrospinal fluid cultures remaining sterile.
Conclusions:
- Adherence to the AAP's 1996 recommendations for LP in simple febrile seizures is suboptimal.
- The study suggests that current guidelines may not reflect contemporary disease epidemiology and etiologies.
- Revisiting and updating the AAP practice parameter for febrile seizures is warranted.
Background:
In 1996, the American Academy of Pediatrics (AAP) published a practice parameter recommending that lumbar puncture (LP) be strongly considered in infants younger than 12 months presenting with a first febrile seizure.
Objective:
We sought: (1) to determine if the recommendations of the AAP are being followed by pediatric emergency medicine-trained physicians at our institution; (2) to describe the rate of meningitis among patients with febrile seizure who underwent LP; and (3) to determine if there were differences in performance of LP if children were younger or pretreated with antibiotics.
Methods:
A retrospective chart review of patients aged 6 to 12 months presenting with first simple febrile seizure to the emergency department (ED) at Miami Children's Hospital was conducted between January 2001 and November 2005.
Results:
A total of 242 ED records with a discharge diagnosis including the term "febrile seizure," "seizure," or "meningitis" were identified. Of those, 56 met inclusion criteria for first simple febrile seizure. Lumbar puncture was performed in 28 patients (50%) that met inclusion criteria. Younger patients were no more likely to have LP performed than older patients (P = 0.15). Ten children (17.8%) received antibiotics before the ED visit; of these, 4 (40%) underwent LP in the ED. Children who presented with first simple febrile seizure to our institution who were pretreated with antibiotics were no more likely to have LP performed than those who were not receiving antibiotics (P = 0.48). All cerebrospinal fluid cultures were sterile.
Conclusion:
The AAP recommendations regarding LP in patients 6 to 12 months of age with first simple febrile seizure are not being strictly adhered to. The AAP recommendations regarding simple febrile seizures were conceived in a different epidemiologic era of disease pathology with data not representative of current prevalence and etiologic issues and need to be revisited.
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