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Updated: Jun 26, 2026

Determining Genetic Expression Profiles in C. elegans Using Microarray and Real-time PCR
10:27

Determining Genetic Expression Profiles in C. elegans Using Microarray and Real-time PCR

Published on: July 30, 2011

Comparative developmental expression profiling of two C. elegans isolates.

Emily J Capra1, Sonja M Skrovanek, Leonid Kruglyak

  • 1Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.

Plos One
|January 1, 2009
PubMed
Summary
This summary is machine-generated.

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Gene expression changes throughout development and differs between C. elegans strains. Innate immunity genes showed unique expression patterns, revealing insights into developmental gene regulation.

Area of Science:

  • Genomics and Developmental Biology
  • Molecular Biology
  • Bioinformatics

Background:

  • Gene expression patterns evolve during development and vary across genetic backgrounds.
  • Previous studies on temporal gene expression in *C. elegans* were limited, with little known about genetic influences.
  • Understanding gene expression variation is crucial for model organism research.

Purpose of the Study:

  • To comprehensively analyze temporal gene expression patterns during *C. elegans* development.
  • To compare gene expression variation between two genetically distinct *C. elegans* isolates.
  • To identify isolate-specific expression changes and their functional implications.

Main Methods:

  • Utilized microarrays covering known and predicted *C. elegans* genes.

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Combined Nucleotide and Protein Extractions in Caenorhabditis elegans
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Combined Nucleotide and Protein Extractions in Caenorhabditis elegans

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A Semi-high-throughput Imaging Method and Data Visualization Toolkit to Analyze C. elegans Embryonic Development
06:49

A Semi-high-throughput Imaging Method and Data Visualization Toolkit to Analyze C. elegans Embryonic Development

Published on: October 29, 2019

Related Experiment Videos

Last Updated: Jun 26, 2026

Determining Genetic Expression Profiles in C. elegans Using Microarray and Real-time PCR
10:27

Determining Genetic Expression Profiles in C. elegans Using Microarray and Real-time PCR

Published on: July 30, 2011

Combined Nucleotide and Protein Extractions in Caenorhabditis elegans
10:37

Combined Nucleotide and Protein Extractions in Caenorhabditis elegans

Published on: March 17, 2019

A Semi-high-throughput Imaging Method and Data Visualization Toolkit to Analyze C. elegans Embryonic Development
06:49

A Semi-high-throughput Imaging Method and Data Visualization Toolkit to Analyze C. elegans Embryonic Development

Published on: October 29, 2019

  • Compared gene expression profiles across developmental stages (egg to young adult).
  • Analyzed gene expression differences between two *C. elegans* isolates.

    • Main Results:

    • Most genes exhibited developmental variation in expression.
    • Significant gene expression differences were observed between the two isolates.
    • A subset of genes, particularly those involved in innate immunity, showed isolate-specific developmental expression changes.
    • Identified novel regulatory motifs and proposed annotations for uncharacterized genes.

    Conclusions:

    • Most genes display dynamic expression during *C. elegans* development, with significant variation between isolates.
    • Innate immunity genes are a key focus for understanding isolate-specific developmental expression.
    • This study enhances understanding of gene expression and function during development and provides a basis for future genetic studies in *C. elegans*.