Related Experiment Video
Updated: Jun 26, 2026
A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
Laparoscopic adrenalectomy for pheochromocytoma: take the vein last?
Melina C Vassiliou1, William S Laycock
1Department of General Surgery, Division of Laparoscopic Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA. melinavassiliou@gmail.com
Background:
Traditionally, the adrenal vein has been ligated early during excision of a pheochromocytoma. Patient anatomy or size of the lesion can sometimes make early vein dissection difficult or unsafe. This study aimed to demonstrate the safety and efficacy of delayed adrenal vein ligation during laparoscopic adrenalectomy for pheochromocytoma.
Methods:
A retrospective review of all laparoscopic adrenalectomies for pheochromocytoma from 1997 to 2007 was conducted. All the patients had confirmed histologic evidence of pheochromocytoma. The procedures were performed using the same technique, which involved division of the adrenal vein late in the procedure after the gland had been dissected free. Patient records were reviewed for evidence of intraoperative hemodynamic variations, blood loss, length of stay, and postoperative morbidity.
Results:
The review examined 27 adrenalectomies performed for 25 patients. Intraoperative hypertension exceeding 170 mmHg was observed in seven patients (26.9%). The overall morbidity was 7.7%, and the mean length of hospital stay was 1.7 days. No deaths occurred.
Conclusions:
Delayed adrenal vein ligation during laparoscopic adrenalectomy for pheochromocytoma is safe and effective. The intraoperative hemodynamic parameters are comparable with those reported in the literature for the "vein first" technique. Dividing the vein late is an alternative approach to laparoscopic excision of adrenal pheochromocytoma and should be considered in appropriate situations.
