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Behavior of endothelial cells regulated by a dynamically changed microenvironment of biodegradable PLLA-PC
Yuanwei Chen1, Niancao Chen, Zhi Qiu
1State Key Laboratory of Polymer Materials and Engineering of China, College of Polymer Science & Engineering, Sichuan University, Chengdu, China.
Abstract:
The influence of PLLA-PC membranes on the behavior of vascular ECs is studied. It was found that the membranes were not cytotoxic. The cell adhesion and spread on PLLA-PC 30/1 were initially depressed. After 1 d, however, cells attached and spread on the copolymer, and proliferated beyond 2 d. To elucidate the mechanism of this behavior, the surface morphology and the degradation products of the PLLA/PC 30/1 membrane during the culture period were tested, and Fg adsorption to the membranes was examined. It is concluded that the behavior of ECs can be regulated by a dynamically changed microenvironment of the PLLA-PC membrane. PLLA-PC copolymers might therefore serve as a novel material for tissue engineering.
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