Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Novel HLA-C*01:303 Allele, Identified in a Living Liver Donor of Canadian Dutch Descendent.

HLA·2026
Same author

Association of Markers of Kidney Tubular Secretion and Risk of Acute Kidney Injury after Acute Heart Failure.

Kidney360·2026
Same author

The Novel DPB1*1927:01N Allele, Identified in a Potential Kidney Donor.

HLA·2026
Same author

Corrigendum to "Adenosine deaminase acting on RNA 1 and receptor-interacting serine/threonine-protein kinase-1 orchestrate the Z-DNA-binding protein 1-mediated PANoptosis and mouse heart transplant rejection" [American Journal of Transplantation Volume 26, Issue 5, May 2026, Pages 962-979].

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same author

Markers of kidney tubule dysfunction and injury and long-term risk of acute kidney injury following coronary artery bypass graft surgery.

PloS one·2026
Same author

Estradiol protects kidney tubules against ferroptosis.

Kidney international·2026

Related Experiment Video

Updated: Jun 26, 2026

In Utero Intra-cardiac Tomato-lectin Injections on Mouse Embryos to Gauge Renal Blood Flow
10:25

In Utero Intra-cardiac Tomato-lectin Injections on Mouse Embryos to Gauge Renal Blood Flow

Published on: February 4, 2015

HIF in kidney disease and development.

Lakshman Gunaratnam1, Joseph V Bonventre

  • 1Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. lgunaratnam@partners.org

Journal of the American Society of Nephrology : JASN
|January 2, 2009
PubMed
Summary

Tissue hypoxia, a hallmark of diseases like cancer and kidney disease, triggers cellular adaptation via hypoxia-inducible factors (HIFs). This review explores HIFs' roles in oxygen sensing and kidney health and disease.

More Related Videos

Evaluation of Zebrafish Kidney Function Using a Fluorescent Clearance Assay
08:13

Evaluation of Zebrafish Kidney Function Using a Fluorescent Clearance Assay

Published on: February 20, 2015

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
07:35

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

Published on: June 23, 2015

Related Experiment Videos

Last Updated: Jun 26, 2026

In Utero Intra-cardiac Tomato-lectin Injections on Mouse Embryos to Gauge Renal Blood Flow
10:25

In Utero Intra-cardiac Tomato-lectin Injections on Mouse Embryos to Gauge Renal Blood Flow

Published on: February 4, 2015

Evaluation of Zebrafish Kidney Function Using a Fluorescent Clearance Assay
08:13

Evaluation of Zebrafish Kidney Function Using a Fluorescent Clearance Assay

Published on: February 20, 2015

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
07:35

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

Published on: June 23, 2015

Area of Science:

  • Cellular Biology
  • Physiology
  • Pathology

Background:

  • Tissue hypoxia is a common pathologic feature in many human diseases, including cancer, myocardial infarction, stroke, and kidney disease.
  • Cells possess an evolutionarily conserved oxygen-sensing mechanism to adapt to hypoxic conditions, maintaining homeostasis through transcriptional activation of various genes.
  • Hypoxia-inducible factors (HIFs) are key oxygen-sensitive proteins controlling the cellular transcriptional response to hypoxia.

Purpose of the Study:

  • To review the mechanisms of oxygen sensing in renal cells.
  • To highlight the role of hypoxia and HIF activation in physiological conditions and renal development.
  • To discuss the contrasting roles of HIFs in acute and chronic kidney diseases.

Main Methods:

  • Literature review of studies on oxygen sensing, hypoxia, and HIFs in renal cells.
  • Analysis of the transcriptional regulation mediated by HIFs.
  • Examination of HIFs' roles in various kidney conditions.

Main Results:

  • Inappropriate HIF system activation is linked to the development and progression of human malignancies, such as clear cell renal cancer.
  • HIFs are implicated in both protective and pathogenic roles in acute and chronic kidney diseases, respectively.
  • Understanding oxygen sensing mechanisms is crucial for comprehending cellular adaptation and disease pathogenesis.

Conclusions:

  • HIFs play critical roles in cellular adaptation to hypoxia and are involved in renal development and disease.
  • The dual role of HIFs in kidney disease necessitates further investigation for therapeutic targeting.
  • This review provides insights into the complex interplay between oxygen sensing, HIFs, and renal pathophysiology.