Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanical Ventilation I: Indication and Settings01:29

Mechanical Ventilation I: Indication and Settings

Mechanical ventilation is a life-saving technique for managing acute respiratory failure and other respiratory complications. The process involves using a machine known as a ventilator to supply oxygen to the lungs and assist in removing carbon dioxide. It serves as a bridge to long-term mechanical ventilation or a temporary measure until ventilatory support is discontinued. The ventilator can maintain this function for a prolonged period, providing critical support for patients until they can...
Mechanical Ventilation II: Invasive Ventilation01:23

Mechanical Ventilation II: Invasive Ventilation

Ventilators are essential medical equipment used to aid patients with respiratory difficulties. Their primary function is to assist or replace spontaneous breathing by providing mechanical ventilation. There are two general classes of mechanical ventilators: negative-pressure and positive-pressure ventilators.
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
Mechanical Ventilation III: Noninvasive Ventilation01:23

Mechanical Ventilation III: Noninvasive Ventilation

Noninvasive positive-pressure ventilation (NIPPV), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BiPAP) are essential methods in respiratory care. These ventilation techniques offer unique benefits for patients with various respiratory conditions, providing adequate support without requiring intubation. Let's explore how each method is crucial in improving patient outcomes and enhancing respiratory therapy.
Noninvasive Positive-Pressure Ventilation (NIPPV)
Acute Respiratory Failure-V01:29

Acute Respiratory Failure-V

The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Assessment of Ventilation I: Respiratory Rate01:20

Assessment of Ventilation I: Respiratory Rate

Assessment of Ventilation
A Ventilation assessment is critical for monitoring a patient's health status. Respiration, one of the most accessible vital signs, provides insights into the function of numerous body systems and can indicate serious health issues, such as brainstem injuries from head trauma.
Critical Guidelines for Assessing Ventilation:
Ventilatory Modes01:14

Ventilatory Modes

Mechanical ventilators are life-saving devices that support or replace spontaneous breathing. They deliver breaths to patients through varying methods known as ventilator modes. Understanding these modes is critical for healthcare providers managing patients with respiratory failure.
There are three ventilatory modes: full support, partial support, and spontaneous. These are described below.
Full Support Modes
Full support modes include controlled mechanical ventilation, continuous mandatory...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Epidemiology and Outcomes Among Adults With Severe Community-Acquired Bacterial Pneumonia Hospitalized in the United States, 2021-2024.

Critical care medicine·2026
Same author

Ventilator-associated pneumonia: newer insights that can drive improved outcomes.

Current opinion in critical care·2026
Same author

Diagnostic Performance of Point-of-Care Immunoassay Measurements of Pancreatic Stone Protein for Sepsis Detection in ICU Patients: A Prospective, Multicenter, Biomarker-Blinded Study.

Critical care medicine·2026
Same author

Antibiotic therapy for severe bacterial infections.

Intensive care medicine·2025
Same author

The Burden of Hospitalization and Rehospitalization Among Patients Hospitalized with Severe Community-Acquired Bacterial Pneumonia in the United States, 2018-2022.

Antibiotics (Basel, Switzerland)·2025
Same author

Ceftobiprole versus ceftriaxone ± linezolid in Community-Acquired Bacterial Pneumonia (CABP): Re-analysis of a randomized, phase 3 study using 2020 FDA guidance.

PloS one·2025

Related Experiment Video

Updated: Jun 26, 2026

3D Cine Magnetic Resonance Imaging of Respiratory Motion in Mechanically Ventilated Mice and Rats
08:22

3D Cine Magnetic Resonance Imaging of Respiratory Motion in Mechanically Ventilated Mice and Rats

Published on: September 19, 2025

Prolonged acute mechanical ventilation: implications for hospital benchmarking.

Marya D Zilberberg1, Andrew A Kramer2, Thomas L Higgins3

  • 1School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA.

Chest
|January 2, 2009
PubMed
Summary

Higher hospital mechanical ventilation (MV) volume is linked to lower mortality for prolonged acute MV (PAMV) patients. However, increased MV volume also correlates with longer hospital stays for these resource-intensive patients.

More Related Videos

A Structured Approach to Extubation in Mechanically Ventilated Rats
05:05

A Structured Approach to Extubation in Mechanically Ventilated Rats

Published on: July 18, 2025

Related Experiment Videos

Last Updated: Jun 26, 2026

3D Cine Magnetic Resonance Imaging of Respiratory Motion in Mechanically Ventilated Mice and Rats
08:22

3D Cine Magnetic Resonance Imaging of Respiratory Motion in Mechanically Ventilated Mice and Rats

Published on: September 19, 2025

A Structured Approach to Extubation in Mechanically Ventilated Rats
05:05

A Structured Approach to Extubation in Mechanically Ventilated Rats

Published on: July 18, 2025

Area of Science:

  • Critical Care Medicine
  • Health Services Research
  • Outcomes Research

Background:

  • Hospital performance metrics often use aggregated outcomes, potentially masking variations in care for specific patient groups.
  • Patients requiring prolonged acute mechanical ventilation (PAMV) are resource-intensive, but their outcomes relative to hospital volume are not well understood.
  • Existing risk adjustment models may not fully capture the complexities of PAMV patient outcomes.

Purpose of the Study:

  • To evaluate if observed outcomes for PAMV patients differed from APACHE IV predictions.
  • To determine the relationship between hospital mechanical ventilation (MV) volume and outcomes in PAMV patients.

Main Methods:

  • Retrospective cohort study utilizing the APACHE IV database (2001-2005).
  • Analysis of 94,553 patients receiving MV across 45 hospitals, with a focus on the 25.8% receiving PAMV (>or= 96 hours).
  • Stratification of PAMV patients by hospital MV volume quintiles to assess mortality and length-of-stay variations.

Main Results:

  • While APACHE IV accurately predicted mortality, it underestimated length-of-stay (LOS) for PAMV patients by 4.6-5.4 days.
  • Standardized mortality ratio (SMR) for PAMV patients showed an inverse relationship with hospital MV volume (higher volume, lower SMR), except in the lowest volume quintile.
  • The discrepancy between actual and predicted MV durations increased proportionally with hospital MV volume.

Conclusions:

  • Hospital MV volume is inversely related to mortality in PAMV patients.
  • PAMV patients disproportionately impact and increase durations of MV, ICU LOS, and hospital LOS, with these excesses rising with hospital MV volume.
  • Specific predictive models for PAMV patients and consideration of STMV vs. PAMV case mix are recommended for performance benchmarking.