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Related Experiment Video

Updated: Jun 26, 2026

Generation of a Gene-disrupted Streptococcus mutans Strain Without Gene Cloning
12:06

Generation of a Gene-disrupted Streptococcus mutans Strain Without Gene Cloning

Published on: October 23, 2017

A phenotypic microarray analysis of a Streptococcus mutans liaS mutant.

Jiaqin Zhang1,2, Indranil Biswas2

  • 1Department of Parasitology, Shandong University School of Medicine, 44# Wenhua Xi Road, Jinan, Shandong 250012, PR China.

Microbiology (Reading, England)
|January 2, 2009
PubMed
Summary
This summary is machine-generated.

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The liaS mutant of Streptococcus mutans shows increased tolerance to various antibiotics targeting protein, DNA, and cell-wall synthesis. This finding highlights LiaS

Area of Science:

  • Microbiology
  • Oral Health
  • Bacterial Pathogenesis

Background:

  • Streptococcus mutans is a primary cause of dental caries.
  • The LiaS histidine kinase regulates virulence factors in S. mutans.

Purpose of the Study:

  • To investigate the role of LiaS in S. mutans physiology and antibiotic susceptibility.
  • To characterize the phenotypes of a liaS mutant using comprehensive analysis.

Main Methods:

  • Phenotypic microarray (PM) analysis of approximately 2000 phenotypes.
  • Growth studies and antibiotic susceptibility testing (disc diffusion, E-test).

Main Results:

  • The liaS mutant exhibited increased tolerance to inhibitors of protein, DNA, and cell-wall synthesis.

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Last Updated: Jun 26, 2026

Generation of a Gene-disrupted Streptococcus mutans Strain Without Gene Cloning
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  • Mutant strain IBS148 showed altered utilization of various nutrient sources.
  • Confirmed enhanced tolerance to specific antibiotics.

    • Conclusions:

    • LiaS plays a significant role in S. mutans' response to cell-envelope stress and antibiotic challenges.
    • Targeting LiaS could be a strategy to enhance dental caries prevention or treatment.