Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 26, 2026

Synthesis and Characterization of Placental Chondroitin Sulfate A (plCSA)-Targeting Lipid-Polymer Nanoparticles
05:55

Synthesis and Characterization of Placental Chondroitin Sulfate A (plCSA)-Targeting Lipid-Polymer Nanoparticles

Published on: September 18, 2018

Enhanced electrostatic interaction between chitosan-modified PLGA nanoparticle and tumor.

Rui Yang1, Won-Sik Shim, Fu-De Cui

  • 1Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea.

International Journal of Pharmaceutics
|January 3, 2009
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Metabologenomic Hallmark-Based Discovery of Bacterial Thioamides as a New Lead against Drug-Resistant Pancreatic Cancer.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Stilbenoid gaylussacin modulates particulate matter-induced chromatin remodeling in macrophages to suppress chronic obstructive pulmonary disease.

Signal transduction and targeted therapy·2026
Same author

Gaylussacin, a stilbene glycoside, inhibits chronic obstructive pulmonary disease in mice.

Redox biology·2025
Same author

Synthesis of Mesoporous Polydopamine-Coated Upconversion Nanoparticles for Dual-Enhanced Photodynamic and Photothermal Cancer Therapy.

International journal of nanomedicine·2025
Same author

Radiopaque hydrogel-in-liposomes towards theranostic applications for malignant tumors.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2025
Same author

Breakthroughs in deep tumour penetrating nano-phototheranostics for tumour ablation.

Clinical and translational medicine·2025

Chitosan-modified nanoparticles target lung tumors by interacting with the acidic tumor microenvironment. This pH-dependent electrostatic interaction enhances paclitaxel accumulation and efficacy in lung cancer models.

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Pharmacology

Background:

  • Previous studies demonstrated lung tumor-specific targeting of paclitaxel using chitosan-modified PLGA nanoparticles (C-NPs-paclitaxel) in mice.
  • A proposed mechanism involved transient aggregate formation and capillary trapping for lung accumulation.

Purpose of the Study:

  • To investigate the underlying mechanism of lung tumor preferential accumulation of paclitaxel delivered via C-NPs-paclitaxel.
  • To examine the influence of pH on nanoparticle properties and cellular interactions.

Main Methods:

  • Evaluated zeta potential of C-NPs-paclitaxel at varying pH (6.8, 7.4, 8.0).
  • Assessed in vitro cellular cytotoxicity of C-NPs-paclitaxel against A549 and CT-26 cells.
  • Measured in vitro uptake of coumarin 6 from C-NPs-coumarin 6 into A549 and CT-26 cells at different pH levels.

More Related Videos

Preparation and Characterization of SDF-1α-Chitosan-Dextran Sulfate Nanoparticles
12:00

Preparation and Characterization of SDF-1α-Chitosan-Dextran Sulfate Nanoparticles

Published on: January 22, 2015

Related Experiment Videos

Last Updated: Jun 26, 2026

Synthesis and Characterization of Placental Chondroitin Sulfate A (plCSA)-Targeting Lipid-Polymer Nanoparticles
05:55

Synthesis and Characterization of Placental Chondroitin Sulfate A (plCSA)-Targeting Lipid-Polymer Nanoparticles

Published on: September 18, 2018

Preparation and Characterization of SDF-1α-Chitosan-Dextran Sulfate Nanoparticles
12:00

Preparation and Characterization of SDF-1α-Chitosan-Dextran Sulfate Nanoparticles

Published on: January 22, 2015

Main Results:

  • Zeta potential of C-NPs-paclitaxel became more positive (increased) as the medium pH decreased (became more acidic).
  • In vitro uptake of C-NPs-coumarin 6 by A549 and CT-26 cells was significantly enhanced at lower pH.
  • In vitro cytotoxicity of C-NPs-paclitaxel showed increased efficacy at more acidic pH levels.

Conclusions:

  • Enhanced electrostatic interaction between chitosan-modified PLGA nanoparticles and the acidic tumor microenvironment is a key mechanism for lung tumor-specific accumulation of paclitaxel.
  • The pH-dependent behavior of C-NPs-paclitaxel contributes to targeted drug delivery and improved therapeutic outcomes in lung cancer.