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Updated: Jun 26, 2026

Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis
Published on: October 15, 2021
HLA class II and autoimmunity: epitope selection vs differential expression
1Institute of Immunology, University of Rostock, 18057 Rostock, Germany. brigitte.mueller-hilke@med.uni-rostock.de
Abstract:
Autoimmune diseases like rheumatoid arthritis (RA), multiple sclerosis, psoriasis and insulin-dependent diabetes mellitus are subject to a complex pathogenesis controlled by multiple genes and numerous environmental factors. The strongest genetic association is with certain HLA class II haplotypes and we here summarize the evidence supporting differential expression as a mechanism supporting the autoimmune process.
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