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Acquired cutis laxa associated with heavy chain deposition disease
Cynthia R Harrington1, Tracy C Beswick, Joseph S Susa
1Department of Dermatology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390-9190, USA.
Abstract:
Acquired cutis laxa (generalized acquired elastolysis) is a condition of unknown etiology characterized by a degeneration of elastic fibers in the skin, resulting in laxity with reduced elastic recoil. We describe a patient with acquired cutis laxa associated with an underlying heavy chain deposition disease. Direct immunofluorescence testing of lesional skin demonstrated immunoglobulin G deposition on elastic fibers, suggesting that in some cases, cutis laxa may have an immune-mediated etiopathogenesis.
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