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UV induction of LexA independent proteins which could be involved in SOS repair
1Laboratoire de Pharmacologie et de Toxicologie Fondamentales, CNRS 205, Toulouse, France.
Biochimie
|April 1, 1991
Abstract:
The SOS response is induced in E coli following treatments that interfere with DNA replication. The response is under the control of the recA and the lexA genes. Strains defective in LexA repressor constitutively express SOS proteins. However, SOS repair does not reach its maximum level in these strains. Instead, an activation of RecA protein and de novo protein synthesis are required for full repair. We have analyzed by 2-dimensional gel electrophoresis the induction of proteins after UV irradiation of lexA(Def) bacteria. Proteins which might participate in SOS repair are induced under these conditions.