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Updated: Jun 26, 2026

In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse
07:46

In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse

Published on: October 25, 2024

[Research advances in Th17 cells]

Xin-Gui Dai1, Yong-Ming Yao, Yu-Hang Ai

  • 1Burn Institute, First Hospital Affiliated the Chinese PLA General Hospital, Beijing 100037, China.

Sheng Li Ke Xue Jin Zhan [Progress in Physiology]
|January 6, 2009
PubMed

CD4+ T cells have been divided into different subsets, essentially based on the cytokines they produce. These subsets include T helper cell (Th)1, Th2 and regulatory T cells (Treg). Recently, another subpopulation of T cells has been identified, and it was named as Th17, which is characterized by the release of interleukin (IL)-17. The discovery of Th17 cells is not only a challenge to some traditional theories, such as the differentiation of CD4+ T cells and the drift theory of Th1/Th2, but also provides new research approach to inflammatory and immunologic diseases, especially, the balance among Th1, Th2, Treg and Th17 cells may play an important role in maintaining the normal immune response.

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