Related Experiment Videos
Study of bioequivalence of magnesium and sodium valproates
A Balbi1, E Sottofattori, M Mazzei
1Istituto di Scienze Farmaceutiche, Università di Genova, Italy.
Journal of Pharmaceutical and Biomedical Analysis
|January 1, 1991
Abstract:
The in vivo bioavailability of magnesium valproate (500 and 1000 mg) enteric-coated tablets has been compared with that of sodium valproate (Depakine) (500 and 1000 mg) enteric-coated tablets. The two preparations were found to be bioequivalent; magnesium valproate appeared to be a drug without bioavailability problems and with reduced inter-subject variability, compared with that of sodium valproate. A reversed-phase HPLC method for the determination of valproates is described.