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Updated: Jun 26, 2026

Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice
Published on: November 18, 2022
Autologous hematopoietic stem cell transplantation for type 1 diabetes
Júlio C Voltarelli1, Carlos E B Couri, Ana B P L Stracieri
1Department of Clinical Medicine, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, Brazil. jcvoltar@fmrp.usp.br
Abstract:
In this review, we present (1) the scientific basis for the use of high-dose immunosuppression followed by autologous peripheral blood hematopoietic stem cell transplantation for newly diagnosed type 1 diabetes (T1D); (2) an update of the clinical and laboratory outcome of 20 patients transplanted at the University Hospital of the Ribeirão Preto Medical School, University of São Paulo, Brazil, and followed up to January/2008, including 4 relapses among 19 patients without previous ketoacidosis; (3) a commentary on criticisms to our article that appeared in four articles from the scientific literature; and (4) a discussion of the prospectives for cellular therapy for T1D.
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