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Related Experiment Video

Updated: Jun 26, 2026

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

Published on: August 13, 2019

Estrogen and urinary incontinence.

Kozo Hirai¹, Hiroshi Tsuda

¹Minamimorimachi Ladies' Clinic, Osaka, Japan. hiraik@mm-clinic.com

International Journal of Urology : Official Journal of the Japanese Urological Association

|January 6, 2009

Summary

This summary is machine-generated.

Hormone therapy (HT) may not improve urinary incontinence (UI) in postmenopausal women. Recent trials show potential adverse effects, suggesting HT should not be used for UI prevention or relief.

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An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

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Published on: August 13, 2019

Recurrent Escherichia coli Urinary Tract Infection Triggered by Gardnerella vaginalis Bladder Exposure in Mice

Recurrent Escherichia coli Urinary Tract Infection Triggered by Gardnerella vaginalis Bladder Exposure in Mice

Published on: December 4, 2020

Area of Science:

Gynecology
Urology
Endocrinology

Background:

Hormone therapy (HT) is a common treatment for postmenopausal disorders.
Lower urinary tract symptoms, including urinary incontinence (UI), are prevalent in postmenopausal women.
Previous understanding suggested HT might improve UI, but evidence was limited.

Purpose of the Study:

To review the effects of HT on UI in postmenopausal women.
To evaluate recent large randomized clinical trials concerning HT and UI.

Main Methods:

Review of recent large randomized clinical trials.
Analysis of evidence regarding estrogen's impact on UI.

Main Results:

Limited prior evidence supported HT's benefit for UI.
Recent trials indicate adverse effects of estrogen on UI.
Current evidence suggests HT is not recommended for UI prevention or relief.

Conclusions:

HT is not recommended for the prevention or relief of urinary incontinence in postmenopausal women.
Estrogen therapy may have adverse effects on UI.
Clinical practice regarding HT for UI needs re-evaluation based on new evidence.